Giant Monsters Are attacking Crystal Cove which eventually causes Mayor Fred Jones Sr. to ask Mystery Incorporated and Sheriff Stone to help stop whoever is behind the attacks. Fred comes up with the idea that the gang should start wearing team uniforms, which Fred's dad thinks are ridiculous.
- Patrick Warburton - Sheriff Bronson Stone
- Frank Welker - Scooby Doo, Fred Jones, Humongounauts
- Troy Baker - Red Humongonaut
- Matthew Lillard - Shaggy
- Grey Delisle - Daphne
- Mindy Cohn - Velma
- Gary Cole - Mayor Skip Sr.
- Tom Kenny - Maxx and Jaxx Minner
- Lewis Black - Mr. E
- Vivica A. Fox - Angel Dynamite
- Fred Tatasciore - Mr. Gnales